A Case of Malignant Ampullary Ulceration

Authors

  • Peter Iskander The Wright Center for GME https://orcid.org/0000-0002-4437-7972
  • Hany Eskarous The Wright Center for GME
  • Mina Daniel The Wright Center for GME
  • Khadijah Sajid
  • Farah Kanith J.W. Ruby Memorial Hospital
  • Aman Ali Wilkes-Barre General Hospital

Keywords:

ampullary carcinoma, cancer

Abstract

Ampullary carcinomas, as the name suggests, are rare tumors that are associated with the ampulla of Vater. Due to their location, symptoms may arise relatively faster than other similar malignancies. Because of this, they can typically be identified sooner, yielding better prognosis and survival outcomes. They are diagnosed via pathology; usually from biopsies obtained while performing EUS/ERCP. Management revolves around resection if able to, or chemo/radiation if deemed unresectable or evidence of metastasis is noted. We present a case of a female presenting with abdominal pain associated with jaundice and scleral icterus. The endoscopic evaluation noted ampullary ulceration with biopsies proven to be notable for moderately differentiated adenocarcinoma. 

References

Al-Jumayli M, Batool A, Middiniti A, et al.: Clinical Outcome of Ampullary Carcinoma: Single Cancer Center Experience. J Oncol. 2019, 2019:3293509. 10.1155/2019/3293509

Rizzo A, Dadduzio V, Lombardi L, Ricci AD, Gadaleta-Caldarola G: Ampullary Carcinoma: An Overview of a Rare Entity and Discussion of Current and Future Therapeutic Challenges. Curr Oncol. 2021, 28:3393–402. 10.3390/curroncol28050293

Balci S, Basturk O, Saka B, et al.: Substaging Nodal Status in Ampullary Carcinomas has Significant Prognostic Value: Proposed Revised Staging Based on an Analysis of 313 Well-Characterized Cases. Ann Surg Oncol. 2015, 22:4392–401. 10.1245/s10434-015-4499-y

Zimmermann C, Wolk S, Aust DE, et al.: The pathohistological subtype strongly predicts survival in patients with ampullary carcinoma. Sci Rep. 2019, 9:12676. 10.1038/s41598-019-49179-w

Wakasugi M, Tanemura M, Furukawa K, et al.: Signet ring cell carcinoma of the ampulla of Vater: Report of a case and a review of the literature. Int J Surg Case Rep. 2015, 12:108–11. 10.1016/j.ijscr.2015.05.031

Zheng-Pywell R, Reddy S: Ampullary Cancer. Surg Clin North Am. 2019, 99:357–67. 10.1016/j.suc.2018.12.001

Romiti A, Barucca V, Zullo A, et al.: Tumors of ampulla of Vater: A case series and review of chemotherapy options. World J Gastrointest Oncol. 2012, 4:60–7. 10.4251/wjgo.v4.i3.60

Askew J, Connor S: Review of the investigation and surgical management of resectable ampullary adenocarcinoma. HPB (Oxford). 2013, 15:829–38. 10.1111/hpb.12038

Walter D, Schnitzbauer AA, Schulze F, Trojan J: The Diagnosis and Treatment of Ampullary Carcinoma. Dtsch Arztebl Int. 2023, 120:729–35. 10.3238/arztebl.m2023.0195

Maselli R, de Sire R, Fugazza A, et al.: Updates on the Management of Ampullary Neoplastic Lesions. Diagnostics (Basel). 2023, 13:. 10.3390/diagnostics13193138

Tsagkalidis V, Langan RC, Ecker BL: Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment. Cancers (Basel). 2023, 15:. 10.3390/cancers15245772

Rizzo A, Dadduzio V, Lombardi L, Ricci AD, Gadaleta-Caldarola G: Ampullary Carcinoma: An Overview of a Rare Entity and Discussion of Current and Future Therapeutic Challenges. Curr Oncol. 2021, 28:3393–402. 10.3390/curroncol28050293

Ahn DH, Bekaii-Saab T: Ampullary cancer: an overview. Am Soc Clin Oncol Educ Book. 2014, 112–5. 10.14694/EdBook_AM.2014.34.112

Panzeri F, Crippa S, Castelli P, et al.: Management of ampullary neoplasms: A tailored approach between endoscopy and surgery. World J Gastroenterol. 2015, 21:7970–87. 10.3748/wjg.v21.i26.7970

Downloads

Published

2026-01-11

How to Cite

Iskander, P., Eskarous, H., Daniel, M., Sajid, K., Kanith, F., & Ali, A. (2026). A Case of Malignant Ampullary Ulceration. The Scholarly Society of America, 4(1), 24–30. Retrieved from https://ssajm-online.org/ojs/index.php/SSAJM/article/view/41

Issue

Section

Case Reports

Most read articles by the same author(s)