A rare case of liver granulomatous disease secondary to Argyria

Authors

  • Ronakkumar Patel MD The Wright Center for GME, Scranton, PA
  • Syed Muhammad Hussain MD The Wright Center for GME, Scranton, PA
  • Salman Abdul Basit MD The Wright Center for GME, Scranton, PA
  • Muhammad Hassan Shakir MD The Wright Center for GME, Scranton, PA
  • Muhammad Waqas MD The Wright Center for GME, Scranton, PA
  • Peter Iskander MD The Wright Center for GME, Scranton, PA
  • Fatima Tanweer MD Dow Medical College, Karachi, Pakistan
  • Mina Daniel MD Memorial Hermann The Woodlands Medical Center, The Woodlands, TX
  • Nirali Patel MD The Wright Center for GME, Scranton, PA

Keywords:

silver toxicity, Argyria, liver granulomas

Abstract

Abstract:

This case report discusses a rare occurrence of liver granulomatous disease secondary to Argyria, a skin disorder resulting from silver exposure. A 61-year-old male presented with fatigue, weakness, and bluish skin discoloration. A diagnostic workup revealed liver granulomas and silver deposits on pathology. History was significant for prolonged ingestion of silver tablets which prompted treatment cessation, antibiotic therapy, and a tapering course of Prednisone. Argyria's association with liver granulomatous disease emphasizes the need for awareness and comprehensive diagnostic evaluation in such cases.

References

Jerger SE, Parekh U. Argyria. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK563123/

Simon M, Buchanan JA: Argyria, an Unexpected Case of Skin Discoloration From Colloidal Silver Salt Ingestion. J Emerg Med. 2020, 59:e39–41. 10.1016/j.jemermed.2020.05.011

Prescott RJ, Wells S: Systemic argyria. J Clin Pathol. 1994, 47:556–7. 10.1136/jcp.47.6.556

Rosenman KD, Seixas N, Jacobs I: Potential nephrotoxic effects of exposure to silver. Br J Ind Med. 1987, 44:267–72. 10.1136/oem.44.4.267

White JML, Powell AM, Brady K, Russell-Jones R: Severe generalized argyria secondary to ingestion of colloidal silver protein. Clin Exp Dermatol. 2003, 28:254–6. 10.1046/j.1365-2230.2003.01214.x

Kwon HB, Lee JH, Lee SH, Lee AY, Choi JS, Ahn YS: A case of argyria following colloidal silver ingestion. Ann Dermatol. 2009, 21:308–10. 10.5021/ad.2009.21.3.308

Kubba A, Kubba R, Batrani M, Pal T: Argyria an unrecognized cause of cutaneous pigmentation in Indian patients: a case series and review of the literature. Indian J Dermatol Venereol Leprol. 2013, 79:805–11. 10.4103/0378-6323.120735

Wadhera A, Fung M: Systemic argyria associated with ingestion of colloidal silver. Dermatol Online J. 2005, 11:12.

Prescott RJ, Wells S: Systemic argyria. J Clin Pathol. 1994, 47:556–7. 10.1136/jcp.47.6.556

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Published

2024-06-30

How to Cite

Patel , R., Zaidi , S. M. H., Basit, S. A., Shakir , M. H., Waqas, M., Iskander, P., Tanweer, F., Daniel, M., & Patel, N. (2024). A rare case of liver granulomatous disease secondary to Argyria. The Scholarly Society of America, 3(1), 14–17. Retrieved from http://ssajm-online.org/ojs/index.php/SSAJM/article/view/28

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Section

Case Reports

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